As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5315-25-3, name is 2-Bromo-6-methylpyridine, molecular formula is C6H6BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Bromo-6-methylpyridine
To a solution of 2-bromo-6-methylpyridine (40.0 g, 233 mmol) in acetic acid (50 mL) was added CH3CO3H (175 mL, 233 mmol) maintaining temperature below 50 C. After completion of addition the mixture was stirred at 50 C for 15 h and then cooled to room temp. Crushed ice was added and the pH was adjusted to 12 with 40% aqueous KOH solution. After extraction with CHCl3, the combined organic layers were dried over Na2SO4, concentrated in vacuo and crude product was purified by silica-gel using EtOAc: Pentane = 1:1, then DCM : MeOH=10:1 to give 2-bromo-6-methylpyridine 1-oxide. MS (ESI) calcd for C6H6BrNO: 188.96
With the rapid development of chemical substances, we look forward to future research findings about 5315-25-3.
Reference:
Patent; GlaxoSmithKline LLC; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; (583 pag.)EP2768509; (2017); B1;,
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