Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1990-90-5, name is 3-Methylpyridin-4-amine. A new synthetic method of this compound is introduced below., Safety of 3-Methylpyridin-4-amine
To a solution of intermediate 2c (100 mg) in CH2Cl2(7 mL) were consecutively added N,N-Diisopropylethylamine (140 muL), 3-methylpyridin-4-amine (40 mg) and bromotripyrrolidinophosphonium hexafluorophosphate (230 mg) and the mixture was stirred at ambient temperature for 2 h. The volatiles were removed under reduced pressure and the residue was purified by column chromatography (Interchim cartridge50SiHP/25 g, Cy/EtOAc) to yield the desired compound (84% yield). [0430] LC-MS (Method 2): m/z [M+H]+=353.2 (MW calc.=352.39); Rt=0.48 min
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Reference:
Patent; Gruenenthal GmbH; Nordhoff, Sonja; Wachten, Sebastian; Kless, Achim; Voss, Felix; Ritter, Stefanie; US2014/194452; (2014); A1;,
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