Abou-Elkhair, Reham A. I.; Hassan, Abdalla E. A.; Boykin, David W.; Wilson, W. David published the artcile< Lithium Hexamethyldisilazane Transformation of Transiently Protected 4-Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation>, Safety of 2-Amino-3-nitro-6-picoline, the main research area is lithium hexamethyldisilazane transiently protected azabenzimidazole nitrile; DMSO imidazole ring formation; amidine preparation.
Trimethylsilyl-transient protection successfully allowed the use of lithium hexamethyldisilazane to prepare benzimidazole (BI) and 4-azabenzimidazole (azaBI) amidines from nitriles in 58-88% yields. This strategy offers a much better choice to prepare BI/azaBI amidines than the lengthy, low-yielding Pinner reaction. Synthesis of aza/benzimidazole rings from aromatic diamines and aldehydes was affected in DMSO in 10-15 min, while known procedures require long time and purification These methods are important for the BI/azaBI-based drug industry and for developing specific DNA binders for expanded therapeutic applications.
Organic Letters published new progress about Amidines Role: SPN (Synthetic Preparation), PREP (Preparation). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Safety of 2-Amino-3-nitro-6-picoline.