Abramovitch, Rudolph A.; Helmer, Friederike; Liveris, M. published the artcile< Aromatic substitution. XVIII. Kinetics of reactions between some halopyridines and -picolines and their N-oxides with methoxide ion in methanol and in dimethyl sulfoxide. Effect of alkyl groups on rates and orientation in nucleophilic aromatic substitution>, Safety of 3-Chloro-2-methoxypyridine, the main research area is SUBSTITUTION AROM KINETICS; PIRIDINES SUBSTITUTION; KINETICS SUBSTITUTION AROM; AROM SUBSTITUTION KINETICS.
The rates and activation parameters for the reactions of 2-fluoro-, 2-chloro-, 2-bromo-, 2-chloro-3-methyl-, 2-chloro-5-methyl-, 2-bromo-3-methyl-, 2-bromo-5-methyl-, 2,3-dichloro-, 2,5-dichloro-, 2-chloro-3-nitro-, and 2-chloro-5-nitropyridines, and of 2-bromo-, 2-bromo-3-methyl-, and 2-bromo-5-methylpyridine N-oxides with MeOK in methanol were determined and compared. The kinetics of the reaction of 2-bromo-, 2-bromo-3-methyl-, and 2-bromo-5-methyl-pyridine and methoxide ion in Me2SO containing small amounts of methanol were also determined; the rates were very sensitive to the methanol concentration The rates were in the order 2-halo- > 2-halo-3-methyl- > 2-halo-5-methyl-, and were dependent upon Eact when the halogen was Br but upon ΔS when it was Cl. The effects of the β-substituent in the pyridine nucleus upon the orthopara ratios are discussed in terms of their effects upon the energies and entropies of activation. 29 references.
Journal of the Chemical Society [Section] B: Physical Organic published new progress about Activation energy. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Safety of 3-Chloro-2-methoxypyridine.