The author of 《A nature-inspired design yields a new class of steroids against trypanosomatids》 were Aguilera, Elena; Perdomo, Cintya; Espindola, Alejandra; Corvo, Ileana; Faral-Tello, Paula; Robello, Carlos; Serna, Elva; Benitez, Fatima; Riveros, Rocio; Torres, Susana; Vera de Bilbao, Ninfa I.; Yaluff, Gloria; Alvarez, Guzman. And the article was published in Molecules in 2019. COA of Formula: C6H4BrNO The author mentioned the following in the article:
Chagas disease and Leishmaniasis are neglected endemic protozoan diseases recognized as public health problems by the World Health Organization. These diseases affect millions of people around the world however, efficient and low-cost treatments are not available. Different steroid mols. with antimicrobial and antiparasitic activity were isolated from diverse organisms (ticks, plants, fungi). These mols. have complex structures that make de novo synthesis extremely difficult. In this work, we designed new and simpler compounds with antiparasitic potential inspired in natural steroids and synthesized a series of nineteen steroidal arylideneketones and thiazolidenehydrazines. We explored their biol. activity against Leishmania infantum, Leishmania amazonensis, and Trypanosoma cruzi in vitro and in vivo. We also assayed their genotoxicity and acute toxicity in vitro and in mice. The best compound, a steroidal thiosemicarbazone compound 8 (ID_1260) was active in vitro (IC50 200 nM) and in vivo (60% infection reduction at 50 mg/kg) in Leishmania and T. cruzi. It also has low toxicity in vitro and in vivo (LD50 >2000 mg/kg) and no genotoxic effects, being a promising compound for anti-trypanosomatid drug development. The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0COA of Formula: C6H4BrNO)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.COA of Formula: C6H4BrNO