Akhlaghpasand, Mohammadhosein; Tizro, Mahdi; Raoofi, Amir; Meymand, Arman Zeinaddini; Farhadieh, Mohammaderfan; Khodagholi, Fariba; Khatmi, Aysan; Soltani, Reza; Hoseini, Yadolah; Jahanian, Ali; Boroujeni, Mahdi Eskandarian; Aliaghaei, Abbas published the artcile< Grafted human chorionic stem cells restore motor function and preclude cerebellar neurodegeneration in rat model of cerebellar ataxia>, Reference of 350-03-8, the main research area is cerebellar ataxia chorionic stem cell neurodegeneration; 3-acetylpyridine; Cerebellar ataxia; Chorionic stem cells; Neurodegeneration; Transplantation.
Abstract: Cerebellar ataxia (CA) is a form of ataxia that adversely affects the cerebellum. Cell replacement therapy (CRT) has been considered as a potential treatment for neurol. disorders. In this report, we investigated the neuro-restorative effects of human chorionic stem cells (HCSCs) transplantation on rat model of CA induced by 3-acetylpyridine (3-AP). In this regard, HCSCs were isolated and phenotypically determined Next, a single injection of 3-AP was administered for ataxia induction, and bilateral HCSCs implantation was conducted 3 days after 3-AP injection, followed by expression anal. of a number of apoptotic, autophagic and inflammatory genes as well as vascular endothelial growth factor (VEGF) level, along with assessment of cerebellar neurodegeneration, motor coordination and muscle activity. The findings revealed that grafting of HCSCs in 3-AP model of ataxia decreased the expression levels of several inflammatory, autophagic and apoptotic genes and provoked the up-regulation of VEGF in the cerebellar region, prevented the degeneration of Purkinje cells caused by 3-AP toxicity and ameliorated motor coordination and muscle function. In conclusion, these data indicate in vivo efficacy of HCSCs in the reestablishment of motor skills and reversal of CA.
Metabolic Brain Disease published new progress about Antigens, Thy-1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Reference of 350-03-8.