Synthesis and biological evaluation of some pyridine derivatives as antimicrobial agents was written by Ali Hussen, Dagim;Bekhit, Adnan A.;Hymete, Ariaya. And the article was included in Ethiopian Pharmaceutical Journal in 2009.Formula: C12H8N4O This article mentions the following:
In this study, several pyridine derivatives were prepared and evaluated for their in-vitro antimicrobial activity against Gram-pos. bacteria (Bacillus cereus and Staphylococcus aureus), Gram-neg. bacteria (Escherichia coli and Pseudomonas aeruginosa) and fungi (Aspergillus niger and Candida albicans). The synthesis of the target compounds was achieved using 1-phenylethanone and 1-(4-chlorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde and 1-(4-methylphenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde as starting materials and a second series was obtained using 4-pyridinecarboxaldehyde and amines or hydrazides as starting materials. The products thus obtained [i.e., 1,2-dihydro-4-[1-(aryl)-3-phenyl-1H-pyrazol-4-yl]-2-oxo-6-phenyl-3-pyridinecarbonitrile derivatives and Schiff base imines and hydrazides] were confirmed by IR, 1H-NMR, 13C-NMR and elemental anal. An evaluation of the toxicity profile revealed that oral and parenteral LD50s are more than 300 mg/kg and 100 mg/kg, resp., and it was discovered that the title compounds displayed antimicrobial activity. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Formula: C12H8N4O).
2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C12H8N4O