Alshahrani, Saad M. published the artcileEffect of lutrol F grades (poloxamer) on dissolution of hot-melt extruded Kollidon VA64-felodipine matrices, Application In Synthesis of 72509-76-3, the main research area is felodipine poloxamer lutrol F grade dissolution hot melt extrusion.
The objective of this study was to assess the potential of Lutrol F grades as polymeric surfactants for dissolution enhancement of Kollidon VA64-drug matrixes produced by hot-melt extrusion (HME). The poorly soluble model drug felodipine (FEL) with a medium m.p. was selected for this study. Two different grades of Lutrol F (also called Kolliphor P grades) were added into the HME systems to investigate their influence on the drug-incorporated matrixes. Two grades of Lutrols i.e., Lutrol F 68 (KolliphorP 188) and Lutrol F 127 (KolliphorP 407) were studied as polymeric solubilizers. FEL was mixed with KollidonVA64, with or without LutrolF (alone or in combination) at predetermined amounts which resulted in 8 different formulations. Each blend was melt-extruded at the same extrusion conditions. Differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD) analyses were performed to evaluate their physicochem. properties. DSC and PXRD studies suggested the formation of amorphous solid dispersion for all extruded formulations. Dissolution studies revealed that the extrudates with Lutrol F grades exhibited faster and higher release compared to formulations without Lutrol F grades. Formulations with high drug loading, which did not include Lutrol F grades, demonstrated low drug release profiles when compared with the same formulations containing Lutrol F grades. Fourier transform IR (FTIR) studies suggested that a stronger hydrogen bond has occurred between the (-NH) of FEL and (C = O) of the pyrrolidone group in Kollidon VA 64. Overall, these studies suggested the potential of Lutrols in enhancing the dissolution rate of poorly soluble model drug FEL.
Acta Poloniae Pharmaceutica published new progress about Dissolution. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Application In Synthesis of 72509-76-3.