Jeffries, DE; Borza, CM; Blobaum, AL; Pozzi, A; Lindsley, CW in [Jeffries, Daniel E.; Lindsley, Craig W.] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA; [Blobaum, Anna L.; Lindsley, Craig W.] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA; [Blobaum, Anna L.; Lindsley, Craig W.] Vanderbilt Univ, Sch Med, Vanderbilt Ctr Neurosci Drug Discovery, Nashville, TN 37232 USA; [Borza, Corina M.; Pozzi, Ambra] Vanderbilt Univ, Dept Med, Div Nephrol, Nashville, TN 37232 USA; [Pozzi, Ambra] Vet Affairs Med Ctr, Nashville, TN 37232 USA published Discovery of VU6015929: A Selective Discoidin Domain Receptor 1/2 (DDR1/2) Inhibitor to Explore the Role of DDR1 in Antifibrotic Therapy in 2020, Cited 12. SDS of cas: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.
Herein, we report the discovery of a potent and selective dual DDR1/2 inhibitor, 7e (VU6015929), displaying low cytotoxicity, good kinome selectivity, and possessing an acceptable in vitro DMPK profile with good rodent in vivo pharmacokinetics. VU6015929 potently blocks collagen-induced DDR1 activation and collagen-IV production, suggesting DDR1 inhibition as an exciting target for antifibrotic therapy.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem