An article One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles WOS:000455286100019 published article about CROSS-COUPLING REACTIONS; DIRECT C-2 ARYLATION; INTRAMOLECULAR CYCLIZATION; BIOLOGICAL EVALUATION; BOND FORMATION; ARYL HALIDES; INDOLES; GENERATION; AMINES; CONSTRUCTION in [Bzeih, Tourin; Zhang, Kena; Alami, Mouad; Hamze, Abdallah] Univ Paris Sud, Fac Pharm, CNRS, LabEx LERMIT,Lab Chim Therapeut,BioCIS UMR 8076, Rue JB Clement, F-92296 Chatenay Malabry, France; [Bzeih, Tourin; Khalaf, Ali; Hachem, Ali] Lebanese Univ, Lab Med Chem & Nat Prod, Fac Sci 1, Hadath, Lebanon; [Bzeih, Tourin; Khalaf, Ali; Hachem, Ali] Lebanese Univ, PRASE EDST, Hadath, Lebanon in 2019, Cited 65. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Category: pyridine-derivatives
A one-pot Barluenga coupling between N-tosylhydrazones and nitro-benzyl bromide, followed by deoxygenation of ortho-nitrostyrenes, and subsequent cyclization has been developed, providing a new way to synthesize various C2-arylindoles. This method exhibits a good substrate scope and functional group tolerance, and it allows an access to NH-free indoles, which can present a potential utility in medicinal chemistry applications.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem