Adding a certain compound to certain chemical reactions, such as: 82205-58-1, 1-(5-Nitropyridin-2-yl)piperazine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
Step 3: l-(5-Nitropyridin-2-yl)-4-[2-(trifluoromethyl)benzoyl]piperazine: To a stirred solution of 2-(trifluoromethyl)benzoic acid (16.45 g, 86.538 mmol) in dry dichloromethane (150 ml) was added l-(3-dimethylaminopropyl)3-ethylcarbodiimide hydrochloride (14.61 g, 108.172 mmol), 1-hydroxybenzotriazole (11.04 g, 72.115 mmol) and triethylamine (35.113 ml, 252.40 mmol) at 0 “C. After 30 minutes at the same temperature, the Step 2 intermediate (15.00 g, 72.115 mmol) was added and the mixture was slowly allowed to warm to room temperature. The mixture was further stirred overnight at room temperature. The reaction mixture was diluted with dichloromethane (200 ml) and washed with water (2 x 100 ml) and dried over anhydrous Na2SO4. The residue after evaporation of the solvent was triturated with n-pentane to afford 23.4 g of the desired product as a pale yellow solid; IR (KBr) 3435, 3117, 2991, 1641, 1250, 774 cm4; 1H NMR (CDCl3, 300 MHz) delta 3.26-3.40 (m, 2H), 3.65-3.98 (m, 5H), 4.00-4.10 (m, IH), 6.60 (d, J= 9.3 Hz, IH), 7.37 (d, J= 7.5 Hz, IH), 7.51-7.70 (m, 2H), 7.75 (d, J- 7.5 Hz, IH), 8.24 (dd, J= 6.9, 2.7 Hz, IH), 9.03 (d, J= 2.7 Hz, IH); MS (ESI) m/z 381.37 (MH)+.
The synthetic route of 82205-58-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; WO2008/29266; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem