Synthetic Route of 775288-71-6 ,Some common heterocyclic compound, 775288-71-6, molecular formula is C9H12N4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 54 (305 mg , 0.96 mmol), 69 (200 mg, 0.96 mmol) and benzotriazole-l -yl- oxy-tris-(dimethylamino)- phosphonium hexafluorophosphate reagent (637 mg, 1.44 mmol) in anhydrous DMSO (10 mL) was added DIPEA (0.67 mL, 3.84 mmol). The reaction mixture was stirred at room temperature for 12 h. The progress of the reaction mass was monitored by LCMS. The reaction mixture diluted with water (100 rriL) and the resulting mixture was extracted with ethyl acetate (2 x 100 mL). The organic layer was washed with brine (100ml), dried (Na2S04), filtered, and evaporated under vacuum. The crude product was purified by column chromatography to give 40 mg of the desired product. LC-MS: m/z calcd for C23H21N7O5S, 507.52, found: 508.0 (M+H)+. *H NMR (500 MHz, DMSO-d6): deltaEta 3.55 (2H, s, NCH2CH2N), 3.7 (2H, s, NCH2CH2N), 3.75 (2H, s, NCH2CH2N), 3.8 (5H, s, NCH2CH2N & ArOCH3), 6.74 (1H, s, SCHCH), 6.98 (2H, d, J = 10 Hz, ArCH), 7.4 (2H, d, J = 10 Hz, ArCH), 7.5 (1H, d, J = 10 Hz, ArCH), 7.56 (2H, s, NH2), 8.18 (1H, d, J = 10 Hz, ArCH) and 8.26 (1H, d, J = 5 Hz, ArCH).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,775288-71-6, its application will become more common.
Reference:
Patent; GE HEALTHCARE LIMITED; MEDI-PHYSICS, INC.; JONES, Clare; GLASER, Matthias Eberhard; WYNN, Duncan; NAIRNE, James; MOKKAPATI, Umamaheshwar P.; NEWINGTON, Ian, Martin; RANGASWAMY, Chitralekha; JOSE, Jinto; JOHANSSON, Saga; WO2013/90497; (2013); A1;,
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