Analyzing the synthesis route of 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde

At the same time, in my other blogs, there are other synthetic methods of this type of compound,171919-36-1, 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.171919-36-1, name is 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde, molecular formula is C9H8N2O, molecular weight is 160.17, as common compound, the synthetic route is as follows.COA of Formula: C9H8N2O

c) 1-Methyl-3-(methylaminomethyl)-1H-pyrrolo[2,3-b]pyridine According to the procedure of Preparation 40 (c), except substituting 1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (0.4 g, 2.5 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.2 g, 45%) was prepared as a yellow oil: MS (ES) m/e 176 (M + H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,171919-36-1, 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; Affinium Pharmaceuticals, Inc.; EP1226138; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem