Synthetic Route of 694-85-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 694-85-9, name is 1-Methylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below.
i) [(l,6-dihydro-l-methyl-6-oxo-3-pyridinyl)sulfonyl]-, 1,1-dimethylethyl ester carbamic acid; hlorosulfonyl isocyanate (6mL) was added dropwise to a solution of 2-methyl-2-propanol(6.5mL) in DCM (75mL) at 0¡ãC. After 5min, l-methyl-2(lNo.)-pyridinone (9mL) was addeddropwise followed by A^Af-du’sopropylethylamine (14.5mL) also added dropwise. Thereaction mixture was then allowed to warm to room temperature over 18h. E^O (lOOmL) wasadded to the reaction mixture and the organic layer was separated. The aqueous was thenfurther extracted with DCM (2xlOOmL). The combined organic layers were dried (MgSO4),filtered and evaporated to give the subtitle compound as a pale yellow oil. Yield: 7gJH NMR: 5 (CDC13) 1.45 (s, 9H), 3.62 (s, 3H), 6.60-6.64 (m, 1H), 7.69-7.74 (m, 1H), 8.21-8.24 (m, 1H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,694-85-9, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/24823; (2006); A1;,
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