Electric Literature of 10128-91-3 ,Some common heterocyclic compound, 10128-91-3, molecular formula is C7H7NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In a 100 mL round bottom flask,Add 1.53 g (10 mmol) of 2-hydroxynicotinic acid methyl ester,Potassium carbonate 2.76 g (20 mmol), DMF 50 ml,4-fluorochlorobenzyl 1.73g (12mmol), reacted at 50 C for 8h,The DMF was removed by concentration, poured into water, extracted with dichloromethane and concentrated to give an oil.Then directly add ethanol: water: sodium hydroxide (7:3: 1.5 mol) solution 50ml, reaction at 80 C for 0.5h,Concentrated, the reaction solution was adjusted to pH 5-6 with 1M hydrochloric acid, and a large amount of white solid was precipitated and filtered.White (4-fluorobenzyl)-2-oxo-pyridine-3-carboxylic acid solid
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10128-91-3, Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shenyang Pharmaceutical University; Ding Huaiwei; Song Hongrui; Xu Yongnan; (10 pag.)CN108239068; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem