Reference of 1020253-14-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1020253-14-8 as follows.
This compound (14 mg, 0.026 mmol, 26% yield) as a white solid was prepared in a fashion similar to that described for Example 116, here using 116a (42 mg, 0.101 mmol) and 6-chloro-5-fluoronicotinonitrile (24 mg, 0.151 mmol) as starting materials. LC/MS (ESI+) m/z = 538.1 [M+H]+. NMR (400 MHz, CHLOROFORM-d) delta ppm 8.66 (d, J = 2.54 Hz, 1H) 7.97 – 8.02 (m, 1H) 7.70 (dd, J = 7.14, 2.64 Hz, 1H) 7.58 – 7.65 (m, 1H) 7.1 1 (dd, J = 1 1.54, 8.61Hz, lH) 6.62 (d, J = 14.87 Hz, lH) 6.42 (d, J = 14.87 Hz, 1H) 4.58 – 4.92 (m,2H) 3.54 – 3.75 (m, 8 H) 2.10 (t, J = 8.31Hz, 1H) 1.41 (dd, J = 9.59, 5.87 Hz, 1H) 1.08 (t, J = 6.36 Hz, 1H). N peak was not observed.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1020253-14-8, its application will become more common.
Reference:
Patent; AMGEN INC.; ALLEN, Jennifer R.; AMEGADZIE, Albert; BOURBEAU, Matthew P.; CHEN, Jian J.; FROHN, Michael J.; HARRINGTON, Paul E.; LOW, Jonathan D.; MA, Vu V.; NGUYEN, Thomas T.; PICKRELL, Alexander J.; REEVES, Corey; (122 pag.)WO2018/112086; (2018); A1;,
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