Application of 109306-86-7 ,Some common heterocyclic compound, 109306-86-7, molecular formula is C11H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(a) 2-[2-(2-Pyridyl)-phenyl thio]-benzoxazole 2-Mercapto benzoxazole (604 mg; 4 mmole) was reacted with 2-(2-bromophenyl)pyridine (936 mg; 4 mmole) in the presence of KOH (224 mg; 4 mmole) in N-methyl pyrrolidine (16 ml). The mixture was heated under reflux for 6 hours, worked up and flash chromatographed (silica), using ethyl acetate/petroleum ether (2/3) eluant to give the sub-title compound as a pale brown oil (52 mg; 4.3%). m/z 304, 281, 277, 271, 186 (Base Peak), 154, 135.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109306-86-7, its application will become more common.
Reference:
Patent; Fisons plc; US4900751; (1990); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem