1121-60-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A mixture of aldehyde (1mmol) and o-phenylenediamine 1a (1mmol, 108.1 mg) in water (1 mL) were added to dispersed solution of GO (100 wt%, 108.7 mg) in water (2 mL) and the reaction mixture was stirred at 60 C forappropriate time (Table 2). After completion of the reaction(monitored by TLC using n-hexane/EtOAc 9:1 as eluent), theGO was separated by filtration and the solution was extractedwith ethyl acetate (2 5 mL). The GO was washed with warmethanol (about 75 C, 5 10 mL) and then organic layers(EtOAc and ethanol) were combined and dried over anhydroussodium sulfate. The solvents were removed under reducedpressure and the residue left out was purified by chromatographyon a short column of silica gel eluted with n-hexane/ethyl acetate (9:1) to give the corresponding benzimidazoles 2in 78-95%yield (Table 2).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1121-60-4, Picolinaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Khalili, Dariush; Banazadeh, Ali Reza; Bulletin of the Chemical Society of Japan; vol. 88; 12; (2015); p. 1693 – 1706;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem