Electric Literature of 113975-31-8 ,Some common heterocyclic compound, 113975-31-8, molecular formula is C10H13IN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Manufacturing Example 1-2-3: 3-lodo-pyridin-2-ylamine N-(3-lodo-pyridin-2-yl)-2,2-dimethyl-propionamide (66.2 g, 218 mmol) described in Manufacturing Example 1-2-2, a 5 N aqueous solution (200 mL) of sodium hydroxide, and methanol (200 mL) were stirred under reflux for 1 hour and 20 minutes. The reaction solution was returned to room temperature, and then water was added thereto, which was extracted with ethyl acetate three times. The ethyl acetate layers were combined, which was washed once with saturated brine, and then dried over sodium sulfate. The sodium sulfate was removed by filtration, and the solvent was evaporated under a reduced pressure to obtain the titled compound (41 g). 1H-NMR spectrum (DMSO-d6) delta (ppm): 6.00 (2H, brs), 6.32 (1 H, dd, J = 4.8 Hz, 7.2 Hz), 7.87 (1 H, d, J = 7.2 Hz), 7.92 (1 H, d, J = 4.8 Hz).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,113975-31-8, its application will become more common.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2065377; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem