Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115473-15-9, name is 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride. A new synthetic method of this compound is introduced below., 115473-15-9
Into a reaction flask equipped with a stirrer, a condenser, and a thermometer was charged intermediate II-113.16 g,This was dissolved in 15 ml of toluene, and 2.37 g of pyridine was added under stirring.1.91 g of 5,6,7,7a-tetrahydrothieno [3,2-c] pyridin-2 (4H) -one hydrochloride was added portionwise to the reaction system.The reaction was continued at 90 C for 2 h after completion of the dropwise addition.The reaction mixture was washed with 3 x 18 ml of water, the toluene layer was separated, dried over anhydrous sodium sulfate,Filtration and distillation of the toluene under reduced pressure gave 3.8 g of a colorless oily product (HPLC: 98.8%),Rf = 0.53 (single spot, developing solvent; v (petroleum ether): v (ethyl acetate) = 2: 1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,115473-15-9, 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; Tianjin Institute of Pharmaceutical Research; LIU, DENG KE; MU, SHUAI; LIU, YING; NIU, DUAN; TAN, CHU BING; ZHOU, ZHI XING; LIU, CHANG XIAO; (22 pag.)CN103896962; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem