Analyzing the synthesis route of 1227573-02-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1227573-02-5, 3-Bromo-5-fluoroisonicotinaldehyde, other downstream synthetic routes, hurry up and to see.

Application of 1227573-02-5 ,Some common heterocyclic compound, 1227573-02-5, molecular formula is C6H3BrFNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 3-iVtelhyi-5-{4,4,5,5-tetraroethyi-(1 ,3,2]dioxabora.an-2-yl)-3H-benzalphaoxazoi-2- one (138 mg, 0,5 mmoi), 3-Bromo»5~f1uoro~pyridine~4~carbafdehyde (102 mg, 0,5 mmoi), Na2CO3 (2 M in water, 0.75 mL, 1.5 mmoi) and PdCI2(PPh3)2 (17 mg, 0.03 mmoi) in DMF(3 mL) was heated at 1000C for 4 hrs. After concentration, the residue was diluted with DCM and saturated NH4C. solution. After filtration and concentration, the residue was purified by flash column (MeOH-C H2CI2, v/v, 0 – 1.5%) and afforded the title compound (47 mg, 35%). 1H NMR (400.3 MHz, CDCi3): S 3.45 (s, 3H), 6,96 (d, J = 1.7 Hz, 1H), 7.08 (dd, J = 8, 1.7 Hz, 1 H), 7.32 (d, J – 8 Hz, 1H), 8.59 (s, 1H), 8.68 (d, J – 1.3 Hz, I H), 10.07 (s, 1H),

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1227573-02-5, 3-Bromo-5-fluoroisonicotinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; HU, Qi-Ying; PAPILLON, Julien; WO2010/130773; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem