Adding a certain compound to certain chemical reactions, such as: 1228880-68-9, Methyl 3-bromo-5-methylpicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Methyl 3-bromo-5-methylpicolinate, blongs to pyridine-derivatives compound. Quality Control of Methyl 3-bromo-5-methylpicolinate
j0352] To a sealed tube containing methyl 2-chloro-5-me- thylnicotinate (CAS 65 169-43-9) (745 g, 4.01 mmol), Cul (38 mg, 0.2 mmol), LiC1 (169 g, 4.01 mmol), and Pd(PPh3)4 (231 g, 0.2 mmol) in toluene (15 mE) was added 2-(tributyl- stannyl)pyrimidine (1.5 mE, 4.4 mmol), and the reaction mixture was heated at 120 C. overnight. The reaction mixture was diluted with water and extracted with DCM. The combined organic layers were dried over Mg504, filtered and evaporated. Purification via silica gel chromatography (0-50% EtOAc in hexanes) gave the title compound (494 g, 52%). Prepared analogous to intermediate A-66, step Asubstituting methyl 2-chloro-5-methylnicotinate with methyl3-bromo-5-methylpicolinate. MS (ESI) mass calcd. forC,2H,,N302, 229.1; mlz found 230.0 [M+H].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1228880-68-9, Methyl 3-bromo-5-methylpicolinate, and friends who are interested can also refer to it.
Reference:
Patent; Janssen Pharmaceutica NV; COATE, Heather R.; DVORAK, Curt A.; FITZGERALD, Anne E.; LEBOLD, Terry P.; PREVILLE, Cathy; SHIREMAN, Brock T.; (473 pag.)US2016/46640; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem