Reference of 13091-23-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13091-23-1, name is 4-Chloro-3-nitropyridine, molecular formula is C5H3ClN2O2, molecular weight is 158.54, as common compound, the synthetic route is as follows.
Procedure 14 Procedure 14 provides a preparation of 6-azaindazole-3-carboxlic acid from 4-chloro-3-nitropyridine. tert-Butyl ethyl propane-1,3-dioate (26.6 mmol) was added to a suspension of sodium hydride (1.11 g) in tetrahydrofuran (50.0 mL) at 0 C. The reaction mixture was allowed to warm to rt and was maintained for 30 min. The reaction mixture was then cooled to 0 C. and a solution of 4-chloro-3-nitropyridine (12.6 mmol) in tetrahydrofuran/N,N-dimethylformamide (9/1, 10 mL) was added dropwise. The mixture was allowed to warm to rt and was maintained for 1 h. The reaction was quenched with water (50 mL) and was neutralized with acetic acid to a pH of 5 (the color went from dark brown to yellow on neutralization). The mixture was extracted with ethyl acetate (50 mL) and the combined organic layers were washed with brine (25 mL), dried (magnesium sulfate), and concentrated to provide the product in 94% yield.
The chemical industry reduces the impact on the environment during synthesis 13091-23-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok; US2007/78147; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem