Analyzing the synthesis route of 142-08-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound,142-08-5, Pyridin-2(1H)-one, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 142-08-5, name is Pyridin-2(1H)-one. A new synthetic method of this compound is introduced below., 142-08-5

General procedure: To a stirred solution of substituted or unsubstituted 2-pyridone (1 eqiv) in acetic acid (10 ml) was added N-halosuccinamide (1.5 eqiv) and heated to 120 C overnight. The recation mixture was flitered,concentrated, diluted with saturated aqueous NaHCO3 and extracted twice with ethyl acetate. The combined ethyl acetate layers were washed with brine, dried over anhydrous sodium sulfate, filtered,concentrated and purified by combiflash to give C in good to excellent yields.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,142-08-5, Pyridin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; PI INDUSTRIES LTD.; SHANBHAG, Gajanan; DODDA, Ranga Prasad; KAMBLE, Ganesh Tatya; KALE, Yuvraj Navanath; RENUGADEVI, G.; MANJUNATHA, Sulur G; S.P., Mohan Kumar; AUTKAR, Santosh Shridhar; GARG, Ruchi; VENKATESHA, Hagalavadi M; MAVINAHALLI, Jagadeesh Nanjegowda; KLAUSENER, Alexander G.M.; (161 pag.)WO2018/193387; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem