1433822-19-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1433822-19-5, name is 8-Bromo-6-chloro-[1,2,4]triazolo[1,5-a]pyridine. This compound has unique chemical properties. The synthetic route is as follows.
A zeaclion vial was chaied with 8-bmhbzo-[l,24]ffi o[1 a]pyzidir (0.500 g, 2.15rtuml, Example 1, Step A 5-mcephthnpytidim2-ane (0335 2.15 nuriol, ArkPhami1,4-dioxam (10 niLX CsCO (1.40 g, 43] nutol), Xaxtp}rs (0.0522 g, 0.108 rtutiol) and Pd(dba)(0.03 g, 0.11 rturiol), The ieac&iivialwas fhslitd with iuetgen, capred, sthiud and heated to about12X C overnight. Thi reactionwas cccled tortandthendibatedwithDCM (10] niL) an1water(] L).Theoipiuelayerwas septnted,washe1withwater(S] nlL),brine(l0]iuL), aiil diied over NaSO4. After corcenhathig the exhact to drnss, the prcduct was pnifled via silica Iuistta¡Àccraplv elutir with a gradient of 2]-50% ECAc in pe1eum ether to Soid C?-chlcwa-N(Y(0.50 g, 703 %): LCJMS (Table 1, Metlodr)RL 1.7Smin,MS m&331 (M+H).
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Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; FRIEDMAN, Michael M.; COX, Philip; FRANK, Kristine E.; HOEMANN, Michael Z.; OSUMA, Augustine; WILSON, Noel S.; XU, Xiangdong; WO2015/157955; (2015); A1;,
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