Electric Literature of 1461602-59-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1461602-59-4, name is 3-(Methylamino)isonicotinic Acid, molecular formula is C7H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3-(Methylamino)isonicotinic acid (4.00 g, 26.3 mmol), 1-hydroxybenzotriazole (10.7 g, 78.9 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (15.1 g, 78.9 mmol) and ammonium chloride (5.63 g, 105 mmol) were dissolved in N,N-dimethylformamide (5 mL). The reaction solution was stirred at 25C for 24 hours. The reaction was quenched by adding water (100 mL). The mixture was extracted with isopropanol / chloroform (1:3) (50 mL x 2). The organic phases were combined and concentrated under reduced pressure. The residue was added with dichloromethane / methanol (10:1, 30 mL), stirred for 10 minutes, filtered and the filter cake was dried to give 3-(methylamino)isonicotinamide (3.50 g, as a yellow solid) with a yield of 88%. 1H NMR: (400 MHz, DMSO-d6) delta 8.12-8.06(m, 2H), 7.80(d, J = 5.2 Hz, 1H), 7.62-7.61(br, 1H), 7.52-7.48(br, 1H), 7.43(d, J = 5.2 Hz, 1H), 2.84(d, J = 5.2 Hz, 3H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1461602-59-4, 3-(Methylamino)isonicotinic Acid.
Reference:
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; WU, Lingyun; CHEN, Xiaoxin; ZHANG, Peng; LIU, Xing; ZHANG, Li; LIU, Zhuowei; CHEN, Shuhui; LONG, Chaofeng; (160 pag.)EP3299371; (2018); A1;,
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