The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 152460-10-1, name is N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C16H15N5
1,4-Dioxane (75 ml) and thionyl chloride (45.5 ml) were added to p-toluic acid (25 g) and the mixture was heated at 60C for 12 hours. The resulting mass was distilled under vacuum at 50C to produce an oily mass. The resulting oil was slowly added to a stirred suspension of (45.8 g), potassium carbonate (63 g), tetrahydrofuran (238 ml) and N-(5- Amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine at 0C. The resulting mass was stirred for 3 hours at 25C and followed by quenching in a mixture of water (700 ml) and ethyl acetate (92 ml). The resulting mixture was stirred for 2 hours at 25 C and filtered the solid. The solid was washed with water (400 ml) and ethyl acetate (200 ml), and dried in an air oven at 65C for 8 to 10 hours to give 47.5 g of 4-methyl-N-[4-methyl-3-[[4-(3- pyridinyl)-2-pyrimidinyl]amino] phenyl] benzamide (Purity by HPLC: 99.6%).
With the rapid development of chemical substances, we look forward to future research findings about 152460-10-1.
Reference:
Patent; ACTAVIS GROUP PTC EHF; KHUNT, Mayur, Devjibhai; PATIL, Nilesh, Sudhir; PAGIRE, Haushabhau, Shivaji; PRADHAN, Nitin, Sharadchandra; WO2011/95835; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem