Electric Literature of 153034-86-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153034-86-7, name is 2-Chloro-4-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 2-chloro-4-iodopyridine (4.943 g, 20.6 mmol) and formic acid(88%, 10 mL) was stirred at 105 C. for 21 h. The excess of formic acid was removed in vacuo, and the mixture was quenched with 2 M aq Na2CO3, extracted with 0H2Cl2, dried over Na2SO4. After the solvent was removed under reduced pressure, the residue was purified by chromatography on silica gel eluted with CH2Cl2/MeOH to afford 1.716 g (38%) of 4-iodopyridin-2(1H)-one as a solid. LC-MS Method 1 tR=0.82 min, m/z=222 (MH+); 1H NMR (400 MHz, (0D3)2SO) delta 7.14 (d, J=6.5 Hz, 1H), 6.87 (s, 1H), 6.49 (d, J=7.0 Hz, 1H).
According to the analysis of related databases, 153034-86-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH; US2010/331320; (2010); A1;,
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