Reference of 153747-97-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.153747-97-8, name is tert-Butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate, molecular formula is C14H20BrN3O2, molecular weight is 342.23, as common compound, the synthetic route is as follows.
Under nitrogen protection,Tert-butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate (202 mg, 0.59 mmol),N,N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3) ,2-Dioxaborolan-2-yl)pyridin-2-amine (300 mg, 0.49 mmol) andCesium carbonate (320mg, 0.98mmol)Ethylene glycol dimethyl ether/water (10 mL/1 mL)Pd(dppf)Cl2.CH2Cl2 (40 mg, 0.05 mmol) was added to the mixture.The reaction solution is heated to 90C.After stirring overnight, cool to room temperature and filter through celite. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by column chromatography on silica gel (PE/EtOAc (v/v) = 5/1) to give the title compound as a yellow oil (250 mg, 68%).
Statistics shows that 153747-97-8 is playing an increasingly important role. we look forward to future research findings about tert-Butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Liang; Wang Tingjin; (104 pag.)CN104650049; (2018); B;,
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