Adding a certain compound to certain chemical reactions, such as: 15506-18-0, 1-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
[0625] To a solution of 2-(4-(2,4-difluorophenoxy)piperidin-l-yl)-5- (etaiotaomicronphi1etaomicron8Homicronetanu1)rhonupieta-3-3etapietaepsilon (50.00 mg, 1 10.0 muiotaetaomicron, 1.00 eq) and 1 -methyl -2 -oxo- 1,2- dihydropyridine-3-carboxylic acid (20.22 mg, 132.0 mutauetaomicron, 1.20 eq) in DMF (2 mL) was added HATU (62.75 mg, 165,02 muiotaetaomicron, 1.50 eq) and DIPEA (42.65 mg, 330.0 muetaiotaomicron, 57.64 mu,, 3.00 eq). The resulting mixture was stirred at 25C for 12 hours, then diluted with EtOAc (50 mL) and washed with saturated aq N’a >(*<) > (20 rnL) and brine (20 mL). The organic layers were dried over anhydrous NazSC filtered, concentrated in vacuo, and purified by preparative HPLC (basic mode) to give the title compound as a white solid (18 mg, 27%). .H NMR (400 MHz, CDCb) delta ppm 2.09 – 2.27 (m, 4 H), 3.01 – 3.15 (m, 4 H), 3.15 – 3.24 (m, 2 H), 3.54 – 3.63 (m, 2 H), 3.72 (s, 3 H), 3.75 – 3.85 (m, 4 H), 4.42 (dt,./ 7. 1. 3.5 Hz, 1H), 6.49 (t,./ 7. 1Hz, 1H), 6.74 – 6,83 (m, 1 I D. 6.87 (ddd, J=l 1.0, 8.4, 3.1Hz, 1H), 7.03 (td,,7=9.2, 5.5 Hz, 1H), 7.64 (dd, J=6.6, 1.8 Hz, 1H), 8.43 (d, J=2.2 Hz, 1H), 8.60 (dd, J=7.3, 2.0 Hz, 1H), 9.07 (d, J=2.2 Hz, 1H), 12.23 (s, 1H); ESI-MS m/z] M · Pi | 590.0.
The synthetic route of 15506-18-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; GREEN, Jason; HOPKINS, Maria; JONES, Benjamin; KIRYANOV, Andre A.; KUEHLER, Jon; MONENSCHEIN, Holger; MURPHY, Sean; NIXEY, Thomas; SUN, Huikai; (300 pag.)WO2018/183145; (2018); A1;,
Pyridine – Wikipedia,
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