Analyzing the synthesis route of 1658-42-0

With the rapid development of chemical substances, we look forward to future research findings about 1658-42-0.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1658-42-0, name is Methyl 2-(pyridin-2-yl)acetate, molecular formula is C8H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 1658-42-0

General procedure: In a reaction tube 66.0 mg (0.4 mmol) of ethyl 2-(pyridin-2-yl)acetate (1a), 41.6 mg (0.2 mmol) of 1,3-diphenyl-2-propenone (2b), 12.65 mg (0.05 mmol) of I2 and 58.4 mg (0.4 mmol) of DTBP were added to 1.0 mL of 1,2-dichlorobenzene and stirred the reaction mixture at 120 ¡ãC, after 24 h of the reaction time, the mixture was allowed to attain room temperature, and quenched the I2 with Na2S2O3 solution, after adding 10 mL of brine solution to reaction mixture, the organic portion was extractedwith ethyl acetate (3×10 mL) and combined organic layers dried over anhydrous Na2SO4, crude mixture obtained after removal of ethyl acetate under reduced presure was purified by column chromatography to isolate 3a with 87 percent yield.

With the rapid development of chemical substances, we look forward to future research findings about 1658-42-0.

Reference:
Article; Reddy, N. Naresh Kumar; Donthiri, Ramachandra Reddy; Ravi, Chitrakar; Adimurthy, Subbarayappa; Tetrahedron Letters; vol. 57; 30; (2016); p. 3243 – 3246;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem