With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1659-31-0, name is Dipyridin-2-yl carbonate, molecular formula is C11H8N2O3, molecular weight is 216.19, as common compound, the synthetic route is as follows.Computed Properties of C11H8N2O3
Under nitrogen atmosphere, to a stirred mixture of (3S,4R)-2-methyl-4-oxo-3- oxetanylammonium toluene-4-sulfonate (0.100 g, 0.36 mmol) in dry CH2C12 (1 mL), DIPEA (0.060 mL, 0.36 mmol) was added dropwise. Subsequently, the crude mixture containing (1- methyl-5-phenyl-pentyl)-2- oxopyridine 1-carboxylate (0.31 g, 1.02 mmol) dissolved in dry CH2C12 (2 mL) was added. The reaction mixture was stirred 15h at rt, concentrated to dryness and purified by column chromatography using a Teledyne ISCO apparatus, eluting with Cy/TBME (from 100:0 to 70:30). The crude product was further purified by preparative HPLC-MS to afford the title compound (0.035 g, 32%), as a pure mixture (ratio=l : 1) of two diastereoisomers. MS (ESI) m/z: 306 [M-H]+; (ESI) m/z: 304 [M-H] 1HNMR (DMSO-d6): delta 1.12-1.21 (m, 6H), 1.26-1.38 (m, 10H), 1.46-1.64 (m, 8H), 2.52-2.61 (m, 4H), 4.64-4.75 (m, 2H), 4.84 (dq, J= 6.2 Hz, 2H), 5.39 (dd, J= 6.2, 9.3 Hz, 2H), 7.12-7.31 (m, 10H), 8.12 (d, 7= 9.3 Hz, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1659-31-0, Dipyridin-2-yl carbonate, and friends who are interested can also refer to it.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; IIT – ISTITUTO ITALIANO DI TECNOLOGIA; UNIVERSITY DEGLI STUDI DI URBINO; UNIVERSITA DEGLI STUDI DI PARMA; PIOMELLI, Daniele; BANDIERA, Tiziano; MOR, Marco; TARZIA, Giorgio; BERTOZZI, Fabio; PONZANO, Stefano; WO2013/78430; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem