Synthetic Route of 166266-19-9 , The common heterocyclic compound, 166266-19-9, name is 5-Iodo-3-methylpyridin-2-amine, molecular formula is C6H7IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Sodium nitrite (0.708 g, 10.25 mmol) was added to a mixture of 5-iodo-3-methyl-pyridin-2- ylamine (2 g, 8.55 mmol) and H2504 (12 mL) at 0 C. The reactiom mixture was stirred 15 mm at 60C, allowed to cool down, and poured onto crushed ice. Boric acid (1.057 g, 17.09 mmol) was added and the solution was quickly heated to 100 C. The reaction mixture was cooled down and neutralized with a saturated aq. NH4OH solution. The suspension was filtered toafford the crude title product (1.67 g, 7.11 mmol, 83% yield) as a brown solid. tR: 2.85 mm (H PLC 1); tR: 0.62 mm (LC-MS 2); ESl-MS: 236 [M+H] (LC-MS 2).
The synthetic route of 166266-19-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; BLANK, Jutta; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; WO2014/191896; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem