Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16744-81-3, name is 4-Methoxypicolinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H7NO2
4-Methoxypicolinaldehyde (1.9 g, 13.85 mmol), methyl carbamimidothioate hemisulfate (1.93 g, 6.93 mmol), ethyl 2-cyanoacetate (1.57 g, 13.85 mmol) and potassium carbonate (2.30 g, 16.63 mmol) were mixed in 95 ml dry EtOH under N2 and heated at 75 0C for two hours. The suspension was cooled to room temperature and solids were filtered. The solids were suspended in 50 ml H2O and stirred for 30 minutes, filtered, and dried overnight to give the desired product as a red solid (1.04 g, 27percent). 1H NMR (400 MHz, DMSO-D6) delta ppm 2.37 (s, 3H), 3.88 (s, 3H), 7.05 (m, IH), 7.43 (d, J=2.54 Hz, IH), 8.45 (d, J=5.66 Hz, IH). MS m/z calculated for (M + H)+ 275.31, found 275.
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Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2007/84560; (2007); A2;,
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