Synthetic Route of 13228-40-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13228-40-5, name is 2-(2-Pyridyl)indole, molecular formula is C13H10N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2 – (piperidin – 2 – yl) – 1 H – indoleAt room temperature, the compound 6 c (0.5 g, 2 . 57 mmol) dissolved in acetic acid (10 ml), then two platinum oxide (0.116 g, 0 . 514 mmol) is added to the reaction, vacuum, hydrogen replacement for three times, the hydrogen in the lower, 50 C stirring reaction for 4 hours. The reaction liquid filtering, turns on lathe does, then with saturated sodium bicarbonate solution to regulate pH ? 8, aqueous phase methylene chloride (30 ml × 3) extraction, the combined organic phase with saturated salt water (50 ml) washing, anhydrous sodium sulfate drying, filtering, turns on lathe does to obtain a yellow solid compound 6 d (0.35 g, yield: 68%).
According to the analysis of related databases, 13228-40-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Wei Yonggang; Liu Zhenhong; Qin Linlin; (65 pag.)CN106928126; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem