Electric Literature of 13362-28-2 ,Some common heterocyclic compound, 13362-28-2, molecular formula is C6H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A solution of 6-aminopyridinecarboxylic acid 1a-c (1 g, 7.25 mmol) in aq 10% NaOH (5 mL) was added dropwise in 15 min to a solution of aq 10-15% NaOCl (15 mL) at 0 C. After the mixture had been stirred for 1 h at 0 C, additional aq 10-15% NaOCl (10 mL) was added to the reaction mixture. After further stirring (3 h at 5 C), the resulting orange precipitate was filtered through a sintered glass filter. The remaining aqueous filtrate was treated with NaOH pellets (~5 g) to form more precipitate, which was filtered later. The collected solid portions were dissolved in aq 1 M NaOH solution (200 mL) to give a red solution. The red solution was heated to 50 C and treated with active charcoal. The solution was filtered through a pad of Celite (2 cm). The solution was cooled to 10 C, then acidified with concd HCl to pH 3-4. A pale yellow precipitate, which was formed upon acidification was collected by filtration, washed with cold H2O, and dried under reduced pressure to give 2,2′-AzPy-dicarboxylic acids 2a-c as microcrystals (Table 1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13362-28-2, its application will become more common.
Reference:
Article; Avan, Ilker; Synthesis; vol. 48; 3; (2016); p. 365 – 378;,
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