Analyzing the synthesis route of 2-Bromo-4-nitropyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6945-67-1, 2-Bromo-4-nitropyridine, other downstream synthetic routes, hurry up and to see.

Application of 6945-67-1 ,Some common heterocyclic compound, 6945-67-1, molecular formula is C5H3BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Combine 2-bromo-4-nitropyridine (1.00g, 4.93mmol), 4-methylpiperidin-4-ol(709.23mg, 6.16mmol) and cesium carbonate(2.41g, 7.39mmol) dissolved in 30mL In 1,4-dioxane solution, react overnight at 100C. LC-MS detection, the reaction is over,Cool to room temperature, filter, concentrate the filtrate and purify by column chromatography to obtain the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6945-67-1, 2-Bromo-4-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Wang Yong; Zhao Liwen; Wang Yazhou; Quan Xu; Liu Haixuan; Wang Xiaowei; Zhang Yan; Li Xue; Cao Chen; Guo Zhuang; Lv Kunzhi; Wang Hai; Zheng Guochuang; (126 pag.)CN111196804; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem