Analyzing the synthesis route of 2-Bromo-5-methylpyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3510-66-5, 2-Bromo-5-methylpyridine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 3510-66-5 ,Some common heterocyclic compound, 3510-66-5, molecular formula is C6H6BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of compound C1 (78.0 g, 456 mmol) and CuCN (45.2 g, 502 mmol) in 400 nriL of DMF was refluxed for 3 h. The mixture was concentrated under vacuum and the residue purified by chromatography on silica gel (eluent: PE/EtOAc = 10/1) to give 7.7 g of compound C2 as a white solid (Yield: 14.3percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3510-66-5, 2-Bromo-5-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; KREMOSER, Claus; ABEL, Ulrich; STEENECK, Christoph; KINZEL, Olaf; WO2011/20615; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem