Application of 107351-82-6 , The common heterocyclic compound, 107351-82-6, name is 2-Bromo-5-phenylpyridine, molecular formula is C11H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A 100 mL reaction vessel was charged with intermediate A-2 (10 g), Benzimidazole (5 g), KOt-Bu (6.7 g), CuI (0.4 g), Benzotriazole (0.5 g) and dimethylsulfoxide (50 mL) were put together and refluxed under nitrogen for 12 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, and ethyl acetate (1 L) and 0.1 N HCl aqueous solution (1 L) were poured into the flask. The organic layer was separated and washed with 5% brine (1 L). The resulting organic layer was dried over MgSO4, the solvent was removed, and the residue was purified by silica gel column chromatography using an EA: n-hexane (50:50) solvent to obtain Intermediate A-1 (4.98 g).
The synthetic route of 107351-82-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SAMSUNG ELECTRONICS CO., LTD.; SAMSUNG SDI CO., LTD.; KIM, WOOK; CHAE, MI YOUNG; HO, TAL HO; KIM, HYUN JUNG; LEE, KANG MUN; LEE, NAM HEON; (67 pag.)KR2015/131882; (2015); A;,
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