In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7598-35-8, name is 2-Bromopyridin-4-amine, the common compound, a new synthetic route is introduced below. COA of Formula: C5H5BrN2
A 50 mL single necked round bottom flask equipped with reflux condenser, under nitrogen atmosphere, was charged with 2-bromopyridin-4-amine (17) (5.0 g, 28.9 mmol, 1.0 equiv), NaOAc.3H2O (5.90 g, 43.3 mmol, 1.5 equiv), ICl (5.16 g, 31.8 mmol, 1.1 equiv) and glacial acetic acid (19.3 mL) and stirred, at 70 oC, for 16 hours. The reaction mixture was cooled and transferred to a separating funnel and was carefully quenched with portionwise addition of solid powdered NaHCO3 (31.1 g), water (50 mL) and EtOAc (50 mL). The layers were then separated and the aqueous layer was extracted with EtOAc (3 x 50 mL). The combined organic layers were dried over MgSO4 and the volatiles were evaporated. The residue was purified by portionwise flash column chromatography over silica using n-hexane/ EtOAc (99:1 to 50:50) mixtures as eluent to give 2-bromo-5-iodopyridin-4-amine 18 as a light brown solid (3.70 g, 43%). A sample of which had 1H NMR spectral data and low resolution GC/MS (EI) mass spectral data identical to those in the literature
The synthetic route of 7598-35-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Balfour, Michael N.; Zukerman-Schpector, Julio; Rodriguez, Maria Jose Davila; Reis, Joel Savi; Esteves, Carlos Henrique A.; Stefani, Helio A.; Synthetic Communications; vol. 49; 3; (2019); p. 351 – 358;,
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