Application of 23056-40-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23056-40-8, name is 2-Chloro-5-methyl-3-nitropyridine, molecular formula is C6H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of 4 (1.0 g, 6.5 mmol) and c-H2SO4 (27 mL), sodium dichromate (2.5 g) was added slowly. After stirring at rt for 15 h, the mixture was slowly added into cracked ice. The mixture was extracted with EtOAC. The organic extract was washed with brine, dried over Na2SO4, and evaporated in vacuo to provide product 5 as a green solid (1.0 g, 85%). 1H NMR (300 MHz, DMSO-d6) delta: 13.32 (s, 1H), 8.64 (d, J = 2.4 Hz, 1H), 8.37 (d, J = 2.4 Hz, 1H).
According to the analysis of related databases, 23056-40-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; Zhao, Chao; Yang, Su Hui; Khadka, Daulat Bikram; Jin, Yifeng; Lee, Kyung-Tae; Cho, Won-Jea; Bioorganic and Medicinal Chemistry; vol. 23; 5; (2015); p. 985 – 995;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem