Reference of 72830-09-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride. A new synthetic method of this compound is introduced below.
Examples; Starting compounds and intermediates; 2-(3,4-Dimethoxy-pyridine-2-ylmethylsulfanyl)-5-methoxy-3H-imidazo[4,5-b]pyridine A reaction mixture of 10.00 g (55.20 mmol) 5-methoxy-3H-imidazo[4,5-b]pyridine-2-thiol and 12.37 g (55.20 mmol) 2-chloromethyl-3,4-dimethoxy pyridinium chloride in isopropanol (200 ml) is stirred for 2 h under reflux. The mixture is concentrated, filtered and dried at 60C for 16 h. Afterwards the crude hydrochloride of the product is suspended in a mixture of water dichloromethane and is basified to pH 8 by adding sodium hydroxide solution (6 N). The mixture is extracted with dichloromethane three times. The combined organic layers are washed with water, dried over calcium chloride, concentrated in vacuo, reslurried in acetone and dried again in vacuo to give 14.76 g (44.4 mmol / 80 %) of the title product with a melting point of 157.0C (acetone).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,72830-09-2, 2-Chloromethyl-3,4-dimethoxypyridinium chloride, and friends who are interested can also refer to it.
Reference:
Patent; ALTANA PHARMA AG; WO2005/105799; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem