Analyzing the synthesis route of 2-Methyl-3-nitropyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18699-87-1, 2-Methyl-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference of 18699-87-1 ,Some common heterocyclic compound, 18699-87-1, molecular formula is C6H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation 2. l-allyl-2,3-dimemyl-lNo.-pyrrolo[2,3-c]pyridin-7-carbaldehyde; Step 1: 2-formyl-3-nitropyridine; A solution of 2-methyl-3-nitropyridine (10.16 g, 72.46 mmol) prepared in Step 1 ofPreparation 1 and selenium dioxide (8.84 g, 79.71 mmol) in 1,4-dioxane (80 ml) wasrefluxed for 2 days. The reaction mixture was cooled to room temperature and thenfiltered. The filtrate was concentrated under reduced pressure. The resulting residuewas purified with silica gel column chromatography (ethyl acetate/n-hexane=l/2, v/v)to give 12.8 g of the titled compound as red oil.lH-NMR(400MHz, CDCy 5 10.27(s, 1H), 9.00(d, 1H), 8.28(t, 1H), 7.76(d, 1H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18699-87-1, 2-Methyl-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; YUHAN CORPORATION; JANG, Sun-Young; WO2006/25717; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem