Application of 669070-64-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 669070-64-8 as follows.
To the solution of (8) (0.15 g, 0.63 mmol, 1 equiv) in MeOH (1.1 mL), cooled at 0C, SOCI2 (0.07 mL, 0.98 mmol, 1.55 equiv) was slowly added. The reaction mixture was heated at 50C for 16h. After cooling to room temperature the water was added and the mixture was concentrated to 1h of its volume. The residue was adjusted to pH 6 withNaHCOssat, then extracted with EtOAc. The combined organic phases were dried over Mg504 and concentrated to give (9) (0.135 g, 85%) as a beige solid
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,669070-64-8, its application will become more common.
Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE D’ORLEANS; AGROFOGLIO, Luigi; ROY, Vincent; PLEBANEK, Elzbieta; BESSIERES, Maxime; (105 pag.)WO2018/50771; (2018); A1;,
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