Reference of 22280-60-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22280-60-0, name is 6-Chloro-2-methyl-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.
6-methoxy-3-nitro-2-picoline 0.46 gm (20 mMol) sodium were dissolved in 15 mL anhydrous methanol. To this solution were added 2.3 gm 6-chloro-3-nitro-2-picoline in portions. The resulting mixture was stirred for 18 hours at room temperature and then 1 hour at reflux. The reaction mixture was poured into 100 mL of ice water with vigorous stirring. The suspension was filtered and the solid dried at 30C under reduced pressure for 18 hours to provide 2.04 gm (91%) of the desired compound as a tan solid.
According to the analysis of related databases, 22280-60-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ELI LILLY AND COMPANY; EP875513; (1998); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem