Electric Literature of 60010-03-9 ,Some common heterocyclic compound, 60010-03-9, molecular formula is C6H4Cl2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Methylamine (2M in THF, 1.5 L, 3000 mmol) was added to a solution of 2,6-dichloro-4-methyl-3- nitropyridine (Step 1 of Example 1, 295 g, 1425 mmol) THF (4.5 L) while maintaining the temperature at 20C. The reaction mixture stirred for 2 h at rt, diluted with EtOAc (3 L) andwater (5 L). The organic layer was separated and the aqueous layer was extracted with EtOAc (2 L). The combined organic extracts were washed with brine (5 L), dried (Na2504), filtered and the filtrate was evaporated in vacuo at 30C to afford the title compound (285 g, purity 81%) as yellow crystals. Rt: 1.07 mm (LC-MS 1); MS mlz: 201.0 [M] (LC-MS 1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 60010-03-9, 2,6-Dichloro-4-methyl-3-nitropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; BLANK, Jutta; BOLD, Guido; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUeEGER, Heinrich; VAUPEL, Andrea; WO2015/75665; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem