Reference of 58596-89-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58596-89-7, name is 2,6-Dichloro-5-methylpyridin-3-amine, molecular formula is C6H6Cl2N2, molecular weight is 177.0312, as common compound, the synthetic route is as follows.
EXAMPLE A 2,6-Dichloro-3-methyl-5-(3,3-dimethyl-1-triazeno)-pyridine STR15 285 ml of half-concentrated hydrochloric acid are slowly added to 43 g (0.24 mole) of 5-amino-2,6-dichloro-3-methyl-pyridine (Helv. Chim. Acta 59, 190 [1976]), the mixture is cooled to 0, a solution of 17.2 g (0.25 mole) of sodium nitrite in 70 ml of water is added dropwise and the mixture is subsequently stirred at 0 for some time. This diazonium salt solution is added dropwise to a solution of 150 g of sodium carbonate in 430 ml of water and 70 ml of 40-50% strength aqueous dimethylamine solution at 0-3 in the course of 90 minutes and the mixture is subsequently stirred at 0. The precipitate is filtered off with suction, rinsed thoroughly with water and dried under a high vacuum at 40 C. Yield: 49.3 g (88% of theory), melting point: 91-95 C.
Statistics shows that 58596-89-7 is playing an increasingly important role. we look forward to future research findings about 2,6-Dichloro-5-methylpyridin-3-amine.
Reference:
Patent; Bayer Aktiengesellschaft; US4840954; (1989); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem