Analyzing the synthesis route of (2,6-Dimethylpyridin-3-yl)methanol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,582303-10-4, (2,6-Dimethylpyridin-3-yl)methanol, and friends who are interested can also refer to it.

Related Products of 582303-10-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 582303-10-4, name is (2,6-Dimethylpyridin-3-yl)methanol. A new synthetic method of this compound is introduced below.

To a mixture of methyl ( 4-chloro-6-hydroxy-l- benzothiophen-3-yl) acetate (110 mg) and THF (dry) (5 mL) were added (2 , 6-dimethylpyridin-3-yl) methanol (58.8 mg) , tri-n- butylphosphine (0.159 mL) and ADDP (130 mg) at room temperature. The mixture was stirred at room temperature for 12 h. The insoluble material was removed by filtration and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (139 mg) . XH NMR (300 MHz, CDC13) delta 2.54 (3H, s) , 2.57 (3H, s) , 3.73 (3H, s), 4.11 (2H, s), 5.05 (2H, s) , 7.02 (1H, d, J = 7.9 Hz), 7.06- 7.09 (1H, m) , 7.13 (1H, s) , 7.29 (1H, s) , 7.58 (1H, d, J = 7.9 Hz) .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,582303-10-4, (2,6-Dimethylpyridin-3-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKAKURA, Nobuyuki; BANNO, Yoshihiro; TERAO, Yoshito; OCHIDA, Atsuko; MORIMOTO, Sachie; KITAMURA, Shuji; TOMATA, Yoshihide; YASUMA, Tsuneo; IKOMA, Minoru; MASUDA, Kei; WO2013/125732; (2013); A1;,
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