The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 84199-61-1, name is 3-Acetyl-2-bromopyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H6BrNO
General procedure: A mixture of bromide 13 (61.8 mmol), Pd(OAc)2 (140 mg, 0.624 mmol), PPh3 (0.330 g, 1.26 mmol), CuI (22 mg, 0.116 mmol), and 2-prop-2-ynyloxytetrahydropyran (14) (13.0 g, 92.8 mmol) in triethylamine (250 mL) was stirred at 80 C under an argon atmosphere for 16 h. After this period, the mixture was cooled to rt, the precipitate was filtered, and the filtrate was evaporated. The residue was dissolved in EtOAc (700 mL), the solution was washed with saturated aq NaHCO3 (2200 mL), brine (200 mL), dried over Na2SO4, and evaporated in vacuo. The crude product was purified by column chromatography (CHCl3 – MeOH (19:1) (15a-c) or hexanes – EtOAc (2:1) (15d,e) as eluent).
With the rapid development of chemical substances, we look forward to future research findings about 84199-61-1.
Reference:
Article; Subota, Andrii I.; Artamonov, Oleksiy S.; Gorlova, Alina; Volochnyuk, Dmitriy M.; Grygorenko, Oleksandr O.; Tetrahedron Letters; vol. 58; 20; (2017); p. 1989 – 1991;,
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