Application of 185017-72-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 185017-72-5, name is 3-Bromo-2-chloro-6-picoline. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 3-bromo-2-chloro-6-methylpyridine (47.8 mg, 0.231 mmol) and 2- (cyclopentylmethyl) oxazole (35 mg, 0.231 mmol) in DMA (1 mL) was added potassium acetate (45.4 mg, 0.463 mmol) and Pd (PPh3)4(26.7 mg, 0.023 mmol) under N2. The reaction mixture was stirred at 90 overnight. The reaction mixture was cooled to room temperature, filtered and the filtration was concentrated in vacuum, the residue was purified by Prep. TLC (PE: EA 10: 1) to give the title compound. MS: 277.1 (M+1) .1H NMR (CDCl3-d, 400 MHz) : delta 7.95 (d, J 7.8 Hz, 1H) , 7.66 (bs, 1H) , 7.16 (d, J 7.8 Hz, 1H) , 2.82 (d, J 7.0 Hz, 2H) , 2.31-2.39 (m, 1H) , 1.83 (bs, 4H) , 1.65 (bs, 2H) , 1.27 (d, J 5.5 Hz, 2H) .
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 185017-72-5, 3-Bromo-2-chloro-6-picoline.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO., LTD.; BAO, Jianming; HENDERSON, Timothy J.; LO, Michael Man-chu; MAZZOLA, JR., Robert D.; RUDD, Michael T.; TELLERS, David M.; TONG, Ling; LI, Chunsing; NA, Meng; (144 pag.)WO2019/238; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem